Benazepril Hydrochloride Chewable Tablets
Trade Name
LoDan
Product Name
Benazepril Hydrochloride Chewable Tablets
Benazeprilat, the active metabolite of benazepril, is a non-sulfhydryl angiotensin-converting enzyme inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage of the ester group.
Feature
Rapid absorption
Wide distribution
Low toxicity and side effects
No inhibitory effect on the vasopressor response to angiotensin II
Has an antihypertensive effect even in patients with low-renin hypertension
Effective at
Inhibit angiotensin-converting enzyme (ACE) in cats and dogs
Decreased plasma angiotensin II in cats and dogs
Decreased vasopressor activity in cats and dogs
Decreased aldosterone secretion in cats and dogs
Inhibited the degradation of bradykinin in cats and dogs
Lower blood pressure in cats and dogs
Cats and dogs with low-renin hypertension
Indicated for
Treats heart failure, high blood pressure, and some forms of kidney disease in dogs and cats.
Dilates the veins and decreases fluid retention.
Usage & Dosage
Calculate with benazepril hydrochloride. Oral administration, 0.25-0.5mg per 1kg body weight, once daily, or as recommended in the table below.
|
Canine body weight（kg） |
5-10 |
11-20 |
21-40 |
41-80 |
|
Dosage |
1/2 tablet |
1 tablet |
2 tablets |
4 tablets |
According to the clinical efficacy, the dosage can be doubled according to the above dosage.
Precautions
1.LoDan is contraindicated in dogs that are allergic to angiotensin-converting enzyme inhibitors.
2.LoDan should be used with caution on cats or dogs with hyponatremia, coronary or vascular insufficiency, congenital hematopathy, or collagen vascular disease. It is not recommended for pregnant or lactating bitches.
3. When dosing on dogs with severe congestive heart failure, should closely monitor.
4. When dosing on renal insufficiency dogs, the risk of drug accumulation is small, do not need to adjust the dose, but it is recommended to test blood urea and creatinine levels.
Specification
0.5g:5mg
Package
14 tablets/ pack